High-Performance Non-Enzymatic Electrochemical Dopamine Sensors Based on Metal-Organic Framework Derived Co-C-Matrix Nanoplatforms

A facile electrochemical sensing nanoplatform for detection of ultralow dopamine (DA) concentrations is developed through modification cobalt-benzene tricarboxylic acid (Co-BTC) derived cobalt-carbon-matrix (Co-C-matrix). To enhance surface reactions and enzyme-like activities involved in interaction with DA, the structural integration hybrid Co-C-matrix into Co-BTC as metal-organic framework (MOF) investigated, resulting nanostructured transducing media high sensitivity selectivity catalyst. The exhibited improved performance based on electrocatalytic oxidation DA 7176 μ mM −1 cm −2 low limit 10 nM. Furthermore, linearity an amperometry peak toward concentration over wide range from nM to 25 M was observed under optimal conditions. Excellent presence potential interferents operational stability ambient air 30 days well environmental conditions were achieved. practical feasibility these non-enzymatic biosensors demonstrated real samples, where detected human serum outstanding recovery up 100%. synergetic effect Co atoms dispersed matrix carbon nanohybrid results abundant active sites electron transfer pathways.